Sulfone containing bicyclic aromatic ring compounds, their...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 453/02 (2006.01) A61K 31/435 (2006.01) A61K 31/439 (2006.01) A61K 31/495 (2006.01) A61P 25/28 (2006.01) C07D 333/66 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 417/04 (2006.01) C07D 451/02 (2006.01) C07D 451/14 (2006.01) C07D 471/04 (2006.01) C07D 471/08 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2448913

The present invention relates to novel compounds that are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

La présente invention concerne de nouveaux composés dont on a découvert qu'ils étaient des ligands cholinergiques pour les récepteurs nicotiniques de l'acétylcholine et des modulateurs des récepteurs et transporteurs de la monoamine. En raison de leur profil pharmacologique, les composés de l'invention peuvent être utilisés dans le traitement de maladies ou affections aussi diverses que celles qui sont liées au système cholinergique du système nerveux central (SNC), du système nerveux périphérique (SNP), les maladies ou affections liées à la contraction des muscles lisses, les maladies ou affections endocriniennes, les maladies ou affections liées à la neurodégénérescence, les maladies ou affections liées à l'inflammation, la douleur et les symptômes de sevrage entraînés par la fin de la consommation abusive de substances chimiques.

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