A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 38/09 (2006.01) A61K 47/24 (2006.01) A61K 47/34 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2718750
The disclosure provides a method to form sustained release drug-containing microparticles with a biodegradable polymer. The method involves forming a polymer- drug- organic solvent phase, and dispersing the polymer-drug-organic solvent phase in an aqueous suspension of an inorganic gel, which may be hydroxyapatite. The hydroxyapatite appears to coat the polymer-drug-solvent droplets to prevent them coalescing. The solvent then evaporates with stirring of the dispersion, at which time the droplets solidify to drug- containing microparticles. The inorganic gel allows suitably small microparticles to form without use of an organic emulsifier.
La présente invention porte sur un procédé permettant de former des microparticules contenant un médicament à libération prolongée avec un polymère biodégradable. Le procédé comprend la formation dune phase de solvant organique-médicament-polymère, et la dispersion de la phase de solvant organique-médicament-polymère dans une suspension dun gel inorganique pouvant être de lhydroxyapatite. Il apparaît que lhydroxyapatite enrobe les gouttelettes de solvant-médicament-polymère pour empêcher leur coalescence. Le solvant sévapore ensuite lorsque lon brasse la dispersion, et les gouttelettes se solidifient alors pour former des microparticules. Le gel inorganique permet de former de façon appropriée des microparticules, sans avoir à utiliser démulsifiant organique.
Moffat & Co.
The Board Of Trustees Of The University Of Arkansas
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