C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/82 (2006.01) A01H 5/00 (2006.01) C07K 14/81 (2006.01) C12N 15/64 (2006.01) C12N 15/65 (2006.01) C12N 15/90 (2006.01)
Patent
CA 2384932
A method of removing a part of a transgene after its integration into a genome comprising flanking the part of the transgene on each side with an attachment P region (attP) of bacteriophage .lambda. and inducing intrachromasomal homologous recombination between the flanking attP regions so that the part of the transgene sandwiched between the attP regions is removed.
L'invention concerne une technique d'élimination d'une partie d'un transgène après son intégration dans un génome, consistant à flanquer la partie du transgène de chaque côté à l'aide d'une région P de fixation (attP) du bactériophage .lambda. et à induire une recombinaison intrachromosomique homologue entre les régions flanquantes attP, de manière à retirer la partie du gène prise entre les régions attP.
Meyer Peter
Zubko Elena
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of Leeds
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