Use of tgf-b antagonists to limit nephrotoxicity of...

Details Use of tgf-b antagonists to limit nephrotoxicity of... Use of tgf-b antagonists to limit nephrotoxicity of...

A - Human Necessities

61

K

A61K 38/18 (2006.01)

Patent

CA 2581787

The disclosure relates to methods of ameliorating nephrotoxic side effects of immunosuppressive agents whose immunosuppressive activity is mediated via upregulation of TGF-.beta. such as, for example, cyclosporine (CsA). The disclosure provides treatment modalities for use in patients that require immunosuppression, e.g., patients at risk of transplant rejection or having an autoimmune disease. In the methods of the invention, a TGF-.beta. antagonist, e.g., an anti-TGF-.beta. antibody, is administered to a patient treated with an immunosuppressive agent. Such a TGF-.beta. antagonist is administered in a therapeutically effective amount sufficient to alleviate the nephrotoxic effects of the immunosuppressive agent without substantially interfering with immunosuppressive activity of the agent.

L'invention concerne des procédés pour améliorer les effets secondaires néphrotoxiques d'agents immunosuppresseurs dont l'activité d'immunosuppression est provoquée par la régulation à la hausse du TGF-ß comme, par exemple, la cyclosporine (CsA). L'invention concerne des modalités de traitement à appliquer chez des patients nécessitant une immunosuppression, à savoir des patients risquant un rejet de greffe ou souffrant d'une maladie auto-immune. Selon les procédés de l'invention, un antagoniste du TGF-ß, c'est-à-dire un anticorps anti-TGF-ß, est administré à un patient sous traitement par agent immunosuppresseur. Un tel antagoniste du TGF-ß est administré en une quantité thérapeutiquement efficace pour atténuer les effets néphrotoxiques de l'agent immunosuppresseur sans interférer de manière notable avec l'activité d'immunosuppression de l'agent.

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