Improved metered dose inhaler

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61M 15/00 (2006.01) B65D 83/14 (2006.01)

Patent

CA 2525744

The present invention relates to the provision and use of pressurised metered dose inhalers (MDIs) for the effective administration of pharmaceutical aerosol formulations. Such formulations comprise a drug, a propellant comprising one of either 1,1,1,2-tetrafluoroethane (HFA134a) or 1,1,1,2,3,3,3- heptafluoropropane (HFA227) or a mixture thereof, a cosolvent having a higher polarity than HFA134a or HFA227, and a surfactant in an amount at least 0.01 % by weight of said formulation. Such MDIs comprise a canister.

La présente invention concerne un inhalateur-doseur sous pression et son utilisation, cet inhalateur-doseur étant utilisé pour l'administration efficace de formulations pharmaceutiques sous forme d'aérosols. De telles formulations comprennent un médicament, un propulseur comprenant du 1,1,1,2-tétrafluoroéthane (HFA134a) ou du 1,1,1,2,3,3,3-heptafluoropropane (HFA227) ou un mélange de ceux-ci, un co-solvant dont la polarité est supérieure à celle du HFA134a ou HFA227, et un tensioactif correspondant à au moins 0,01 % en poids de ladite formulation. Un tel inhalateur-doseur comprend un contenant.

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