Medical articles having enzymatic surfaces for localized...

A - Human Necessities – 61 – L

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A61L 15/38 (2006.01) A61L 27/22 (2006.01) A61L 27/54 (2006.01) A61L 29/16 (2006.01) A61L 31/16 (2006.01) A61L 33/00 (2006.01) C12N 11/00 (2006.01)

Patent

CA 2478773

An enzymatically active medical article is provided, which comprises a medical article and an enzyme disposed at or near a surface of the medical article such that the medical article is provided with an enzymatically active surface. The enzyme is selected, for example, from the group consisting of protease enzymes, glycosidase enzymes, enzymes that degrade cholesterol esters, enzymes that convert hydrocortisone to cortisone, enzymes that degrade oxalate, and enzymes that generate NO from arginine.

L'invention concerne un article médical enzymatiquement actif comprenant un article médical et une enzyme disposée au niveau ou au voisinage d'une surface de l'article médical de façon que cet article médical présente une surface enzymatiquement active. Par exemple, cette enzyme est choisie dans le groupe constitué par des enzymes protéases, des enzymes glycosidases, des enzymes dégradant les esters de cholestérol, des enzymes convertissant l'hydrocortisone en cortisone, des enzymes dégradant l'oxalate, ainsi que des enzymes produisant du NO à partir de l'arginine.

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