Soluble receptor br43x2 and methods of using

Details Soluble receptor br43x2 and methods of using Soluble receptor br43x2 and methods of using

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2753331

Soluble, secreted tumor necrosis factor receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise one cysteine-rich repeat that is homologous to other tumor necrosis factor receptors, such as transmembrane activator and CAML-interactor (TACI). The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that modulate B cell activation.

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