Multispecific binding molecules

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/52 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2513287

The invention contemplates a composition containing a multispecific ligand containing at least a first ligand binding moiety and a second ligand binding moiety. The first ligand binding moiety specifically binds with a pre-selected first affinity to at least a first ligand. The first ligand has a first biodistribution. The second ligand binding moiety specifically binds with a pre-selected affinity to at least a second ligand. The second ligand has a second biodistribution. The affinity of first and second ligand binding moieties are selected to bias the biodistribution of the multispecific ligand in favour of a selected location of one or both of the ligands.

L'invention concerne une composition qui contient un ligand multispécifique renfermant au moins une première fraction de liaison de ligand et une seconde fraction de liaison de ligand. La première fraction de liaison de ligand se lie spécifiquement avec une première affinité présélectionnée à au moins un premier ligand. Le premier ligand possède une première biodistribution. La seconde fraction de liaison de ligand se lie spécifiquement avec une affinité présélectionnée à au moins un second ligand. Le second ligand possède une seconde biodistribution. Les affinités des première et seconde fractions de liaison de ligand sont sélectionnées pour influencer la biodistribution du ligand multispécifique en faveur d'un emplacement sélectionné de l'un et/ou l'autre des ligands.

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