Anti-bacterial compositions

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

IPC codes

C07K 7/00 (2006.01) A61K 38/00 (2006.01) A61P 31/04 (2006.01) C07K 14/435 (2006.01)

Type

Patent

Patent number

CA 2711972

Description

An isolated protein for use as an antimicrobial agent comprises a plurality of LRR (leucine rich repeat) domains, each LRR domain independently comprising an amino acid sequence of formula (I): (F1LxxLxL(xxZ)YF2) wherein: F1 and F2 are independently, a contiguous amino acid sequence of between 1 and 30 residues; x can be any amino acid; L can be Leu, Ile, Val or Phe; Z can be NxL or CxxL; N is Asn, Thr, Ser or Cys; C is Cys or Ser; and Y = O or 1.

La présente invention concerne une protéine isolée destinée à être utilisée en tant qu'agent antimicrobien et qui comprend une pluralité de domaines LRR (répétition riche en leucine), chaque domaine LRR comprenant indépendamment une séquence d'acides aminés de formule (I) : (F1LxxLxL(xxZ)YF2 ) dans laquelle : F1 et F2 sont, indépendamment, une séquence d'acides aminés contigus comprenant de 1 à 30 résidus ; x peut être tout acide aminé ; L peut être Leu, Ile, Val ou Phe ; Z peut être NxL ou CxxL ; N est Asn, Thr, Ser ou Cys ; C est Cys ou Ser ; et Y = 0 ou 1.

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