C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2745430
The present invention assists in prospectively predicting the metastatic likelihood, and thereby, the likely clinical outcome of breast cancer patients, based on the genotype of the patient, in particular, by determining the relative expression level of a set of genes, or subsets thereof. The present invention provides use of an expression level of a gene set for the identification of animals, optionally patients, likely to progress to an invasive phenotype, the gene set comprising at least some of the genes selected from ABCA1, ADD3, ADFP, ADM, ALDH1A3, AQP3, ARHGAP26, B2M, BAT2D1, BIRC3, BRWD1, C18ORF1, CBLB, CD44, CHKB, CHPT1, CMKOR1, CXCL12, DBN1, EEF1A2, FAS, FLJ11000, FLJ11286, FLRT3, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA- DRB4, HLA-DRB5, HLA-F, HLA-G, HNRPD, IFITM1, IFITM3, INHBB, ISG20, JAG1, JAG2, KITLG, LAMC1, LAP3, LGALS3BP, MYO1B, NME4, PLCB1, PRLR, PSMB9, PXN, RAB14, SEMA3C, SEPP1, SLC6A8, SP100, SP110, STS, TAP1, TMEPAI, TN-FSF10, TRAM1, TRIM14, and WSB1. Methods, arrays and kits for the identification of animals, optionally patients, likely to progress to an invasive phenotype, are also described.
La présente invention facilite la prédiction prospective de la probabilité métastasique, et ainsi, le résultat clinique probable de patientes atteintes de cancer du sein, sur la base du génotype de la patiente, en particulier, par détermination du taux dexpression relatif dun ensemble de gènes, ou de sous-ensembles de ceux-ci. La présente invention concerne lutilisation du taux dexpression dun ensemble de gènes pour lidentification danimaux, éventuellement de patients, susceptibles de progresser vers un phénotype invasif, lensemble de gènes comprenant au moins certains des gènes choisis parmi ABCA1, ADD3, ADFP, ADM, ALDH1A3, AQP3, ARHGAP26, B2M, BAT2D1, BIRC3, BRWD1, C18ORF1, CBLB, CD44, CHKB, CHPT1, CMKOR1, CXCL12, DBN1, EEF1A2, FAS, FLJ11000, FLJ11286, FLRT3, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA- DRB4, HLA-DRB5, HLA-F, HLA-G, HNRPD, IFITM1, IFITM3, INHBB, ISG20, JAG1, JAG2, KITLG, LAMC1, LAP3, LGALS3BP, MYO1B, NME4, PLCB1, PRLR, PSMB9, PXN, RAB14, SEMA3C, SEPP1, SLC6A8, SP100, SP110, STS, TAP1, TMEPAI, TNFSF10, TRAM1, TRIM14, et WSB1. La présente invention concerne en outre des procédés, des matrices et des kits pour lidentification danimaux, éventuellement de patients, susceptibles de progresser vers un phénotype invasif.
Berrar Daniel
Bjourson Anthony
Mcerlean Seona Bernadine
Borden Ladner Gervais Llp
University Of Ulster
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