Compositions and methods for the treatment of parkinson's...

A - Human Necessities – 61 – K

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A61K 31/47 (2006.01) A61K 31/13 (2006.01) A61K 31/355 (2006.01) A61K 31/375 (2006.01) A61K 31/4706 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2416233

This invention provides compositions and methods for increasing cellular respiration of melanized catecholamine neurons, and methods for alleviating symptoms or stopping appearance and/or progression of symptoms of Parkinson's Disease, and methods for preventing symptoms of on-off syndrome associated with treatment with dopamine or a dopamine agonist of a patient suffering symptoms of a disease selected from the group consisting of idiopathic and atypical Parkinson's disease, conditions characterized by nigrostriatal degeneration and multiple system atrophy, said methods comprising administering to said patient an effective amount of a neuromelanin-binding composition having a quinoline ring in a suitable pharmaceutical carrier. Preferably the composition comprises (-)-chloroquine.

La présente invention concerne des compositions et des traitements permettant d'augmenter la respiration cellulaire des neurones catécholaminé mélanisés. L'invention concerne également des traitements permettant d'améliorer les symptômes de la maladie de Parkinson, ou à tout le moins en arrêter la survenue et/ou la progression. L'invention concerne enfin un traitement dirigé contre le syndrome d'alternance entre dyskinésie et bradykinésie associé au traitement par dopamine ou agoniste de la dopamine dans le cas d'un patient présentant les symptômes d'une affection appartenant au groupe des maladies de Parkinson idiopathiques et atypiques et des états caractérisés par une dégénérescence nigro-striée et du syndrome de Shy et Drager. Ce traitement implique l'administration au patient considéré d'une quantité suffisante d'une composition de liaison à la neuromélanine comportant un cycle quinoline dans un excipient pharmaceutiquement compatible. La composition comprend de préférence une (-)-chloroquine.

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