Molecular mimetics of meningococcal b epitopes which elicit...

Details Molecular mimetics of meningococcal b epitopes which elicit... Molecular mimetics of meningococcal b epitopes which elicit...

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 38/08 (2006.01) A61K 39/095 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 7/06 (2006.01) C07K 14/22 (2006.01) C07K 16/12 (2006.01) C12N 15/11 (2006.01) C12P 21/02 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2439428

Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.

Cette invention concerne des mimétiques moléculaires d'un épitope exposé en surface sur la boucle 4 de PorA du sérogroupe B (MenB) de <i>Neisseria meningitidis </i>, sérosoustype P1.2, et des anticorps dirigés contre lesdits mimétiques. On peut utiliser des compositions renfermant de tels mimétiques ou les anticorps de ces mimétiques pour prévenir la maladie de type MenB, et pour diagnostiquer une infection de type MenB.

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