Use of antibodies against specific mhc-peptide complexes

G - Physics – 01 – N

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G01N 33/564 (2006.01) C07K 16/28 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2415353

The invention describes a method to diagnose the autoimmune disease activity by detecting the presence of an autoimmune specific MHC-peptide complex in a patient suffering from an autoimmune disease. The MHC-peptide complex is associated with rheumatoid arthritis. Monoclonals antibodies to be used for this method are also described. The antibodies can also be used for therapeutic purposes.

L'invention concerne un procédé permettant de diagnostiquer l'activité de maladies auto-immunes en détectant la présence d'un complexe de peptides MHC spécifique auto-immun chez un patient souffrant d'une maladie auto-immune. Le complexe de peptides MHC est associé à l'arthrite rhumatoïde. L'invention concerne également des anticorps monoclonaux à utiliser dans ce procédé. Les anticorps peuvent également être utilisés à des fins thérapeutiques.

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