High sensitivity magnetic marker used for immune response...

Details High sensitivity magnetic marker used for immune response... High sensitivity magnetic marker used for immune response...

G - Physics

01

N

G01N 33/541 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2505507

A high sensitivity magnetic marker preferably used for measurement of an immune response by using a SQUID magnetic sensor and a novel technique about the production are disclosed. A magnetic marker composed of magnetic particles and polymer coating the surfaces thereof and used for measurement of an immune response using a SQUID magnetic sensor. The particle diameter of the magnetic particles (preferably ferrite Fe3O4) is 20 to 40 nm. The outside diameter of the magnetic marker is 40 to 100 nm. The surface of the polymer contains a carboxyl group. The magnetic marker is produced by causing the surfaces of the magnetic particles to absorb a hydrophilic macromonomer (preferably polyvinyl pyrrolydone) having a polymerizable vinyl group and having a molecular weight of 500 to 1,000, adding a monomer having a carboxyl group and comprising a hydrophilic vinyl compound and a crosslinking agent, and copolymerizing them.

L'invention porte sur un marqueur magnétique ultrasensible à capteur magnétique SQID servant de préférence à mesurer la réponse immunitaire, et sur sa nouvelle technique de réalisation. Ledit marqueur est fait de particules magnétiques de préférence de ferrite (Fe¿3?O¿4? ) enrobées de polymère présentant un diamètre nu de 20 à 30 nm, et de 40 à 100 nm enrobage compris. La surface du polymère contient un groupe carboxyle. Pour obtenir le marqueur, on fait absorber par les particules magnétiques un macromonomère hydrophile (de préférence du pyrrolidone de polyvinyle ) à groupe vinyle polymérisable, et d'un poids moléculaire compris entre 500 et 1000, puis on ajoute un monomère comportant un groupe carboxyle, un composé vinylique hydrophile et un agent réticulant, que l'on copolymérise.

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