Use of cathepsin k antagonists in bone production

Details Use of cathepsin k antagonists in bone production Use of cathepsin k antagonists in bone production

A - Human Necessities

61

K

A61K 31/336 (2006.01) A61K 39/395 (2006.01) C12N 5/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2652600

The invention regards the modulation of a proteolytic enzyme, Cathepsin K that results in increased bone production by bone-forming cells. Drugs that target this enzyme within bone forming cells and inhibit its activity represent a new class of anabolic, or bone building, therapies. Such drugs are useful in the treatment of diseases or disorders such as osteoporosis, Paget' s disease, metastatic bone cancer, bone fractures, etc.

Selon cette invention, la modulation d'une enzyme protéolytique, la Cathepsine K, entraîne une augmentation de la production osseuse par des cellules formatrices d'os. Les médicaments ciblant cette enzyme dans des cellules formatrices d'os et inhibant son activité représentent une nouvelle catégorie de thérapies anaboliques ou de construction osseuse. Ces médicaments sont utilisés dans le traitement de maladies ou de troubles tels que l'ostéoporose, la maladie de Paget, le cancer osseux métastatique, les fractures osseuses, etc.

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