Spray-dried microparticles as therapeutic vehicles for use...

Details Spray-dried microparticles as therapeutic vehicles for use... Spray-dried microparticles as therapeutic vehicles for use...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/72 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2250478

Microparticles, which are smooth and spherical, and at least 90 % of which have a volume median particle size of 1 to 10 µm, comprise a substantially uniform mixture of an agent for gene therapy and an excipient. For example, a naked or encapsulated gene can thus be administered, using a dry powder inhaler.

La présente invention concerne des microparticules lisses et sphériques, dont au moins 90 % présente un diamètre de particule moyen en volume de 1 à 10 µm, constituées d'un mélange sensiblement homogène d'un agent de thérapie génétique et d'un excipient. Par exemple, un gène nu ou encapsulé peut ainsi être administré au moyen d'un inhalateur à poudre.

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