N-methyldeacetylcolchiceinamide derivatives

Details N-methyldeacetylcolchiceinamide derivatives N-methyldeacetylcolchiceinamide derivatives

C - Chemistry, Metallurgy

07

D

C07D 317/32 (2006.01) A61K 31/16 (2006.01) A61K 31/70 (2006.01) C07C 235/14 (2006.01) C07H 7/02 (2006.01) C07H 7/033 (2006.01)

Patent

CA 2094796

Abstract of the Disclosure N-methyldeacetylcolchiceinamide derivatives represented by the formula Image wherein R denotes a residue obtained by remov- ing COOH from a C3-C7 sugar carboxylic acid, and hydroxyl groups present in the residue may properly be protected with a protecting group for a hydroxyl group. Said N-methyldeacetylcolchiceinamide derivatives have less toxicity and strong effect for inhibiting prolifera- tion of tumor cells, and are expected to be used as a carcinostatic.

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