Treatment for inhibiting the progression of autoimmune disease

A - Human Necessities – 61 – K

Patent

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A61K 38/17 (2006.01) A61K 38/04 (2006.01) C07K 14/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2219877

The progression of autoimmune disease is inhibited by the administration of peptides having the sequences of MHC Class I antigen .alpha.1-domains. These fragments include the amino acids between positions 70 and 91 of the MHC Class I antigens. The onset of IDDM is significantly decreased by the subject treatment.

On inhibe la progression de maladies auto-immunes en administrant des peptides présentant la séquence de domaines .alpha.1 d'antigènes de classe I du CMH. Ces fragments comprennent des acides aminés situés entre les positions 70 et 91 des antigènes de classe I du CMH. On réduit ainsi de manière significative, grâce à ce traitement, l'apparition du diabète sucré insulino-dépendant.

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