Method of conjugating aminothiol containing molecules to...

Details Method of conjugating aminothiol containing molecules to... Method of conjugating aminothiol containing molecules to...

C - Chemistry, Metallurgy

07

K

C07K 17/02 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2595909

The present invention relates to a novel chemical process that provides novel vehicle derivatives that are exceptional 1,2- or 1,3-aminothiol specific reagents for conjugation to unprotected targeted compounds (e.g., polypeptides, peptides, or organic compounds) having or modified to have a 1,2- or 1,3 aminothiol group. The invention further relates to the methods of using novel water-soluble polymer derivatives and conjugates thereof.

La présente invention concerne un nouveau processus chimique permettant d'obtenir de nouveaux dérivés sous forme de véhicules qui sont d'exceptionnels réactifs spécifiques du 1,2-aminothiol ou du 1,3-aminothiol en vue d'une conjugaison à des composés ciblés non protégés (par ex., des polypeptides, des peptides ou des composés organiques) renfermant ou ayant été modifiés de manière à renfermer un groupe 1,2-aminothiol ou 1,3-aminothiol. L'invention concerne également des procédés d'utilisation de nouveaux dérivés polymères hydrosolubles et de leurs conjugués.

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