Heterocyclic derivatives and their use as antithrombotic agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/06 (2006.01) A61K 31/38 (2006.01) A61K 31/47 (2006.01) C07D 217/22 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2287558

The present invention relates to antithrombotic com- pounds comprising the group Q, Q having formula (I), wherein the substructure (i) is a structure selected from (a, b and c), wherein X is O or S; X' being independently CH or N; and m is 0, 1, 2 or 3; wherein the group Q is bound through an oxygen atom or an optionally substituted nitrogen or carbon atom, or a pharmaceutically acceptable salt thereof or a prodrug thereof. The compounds of the invention are therapeutically active and in particular are antithrombotic agents.

La présente invention concerne des composé antithrombotiques comprenant le groupe Q correspondant à la formule (I) dans laquelle la sous-structure (i) est une structure choisie parmi (a), (b) ou (c) où X représente O ou S, X' représente indépendamment CH ou N, et m vaut 0, 1, 2 ou 3, le groupe Q étant fixé au moyen d'un atome d'oxygène ou d'un atome de carbone ou d'azote éventuellement substitué. L'invention concerne également un sel ou un promédicament de ces composés, acceptable sur le plan pharmacologique. Les compositions de l'invention sont actives sur le plan thérapeutique et constituent notamment des agents antithrombotiques.

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