Process for preparing...

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C - Chemistry, Metallurgy

07

F

C07F 9/6512 (2006.01) A61K 31/505 (2006.01) C07C 25/13 (2006.01) C07D 239/42 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2300243

N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2- yl]-N-methylmethanesulphonamide of the formula (see formula I) is prepared by reaction of [4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methylsulphonylamino)pyrimidin-5-yl]methanol with chlorodiphenylphosphine. Compound I is an intermediate in the synthesis of pharmaceutically active compounds, in particular HMG-Co A. reductase inhibitors.

Le N-¬5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2- yl|-N-methylmethanesulphonamide de la formule (voir formule I) est préparé par réaction du ¬4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methylsulphonylamino)pyrimidin-5-yl|méthanol avec de la chlorodiphenylphosphine. Le composé I est un intermédiaire dans la synthèse de composés actifs sur le plan pharmaceutique, en particulier les inhibiteurs de réductase HMG-Co A.

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