C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 45/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2303594
This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, (see formula I) wherein R is as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.
Bereskin & Parr
Pfizer Products Inc.
LandOfFree
Compounds for treating and preventing diabetic complications does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds for treating and preventing diabetic complications, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds for treating and preventing diabetic complications will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1799135