Pyrazole derivatives as reverse transcriptase inhibitors

Details Pyrazole derivatives as reverse transcriptase inhibitors Pyrazole derivatives as reverse transcriptase inhibitors

Category

C - Chemistry, Metallurgy

Subcategory

07

Subsubcategory

D

IPC codes

C07D 417/12 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61P 31/18 (2006.01) C07D 231/28 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Type

Patent

Patent number

CA 2497333

Description

This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R' to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

L'invention concerne des dérivés de pyrazole représentés par la formule (I) ou des sels, des solvates, ou des dérivés pharmaceutiquement acceptables de ceux-ci; dans la formule, R' à R4 sont tels que définis dans la description. Cette invention concerne également des procédés de préparation, des produits intermédiaires utilisés lors de la préparation de ces dérivés de pyrazole, des compositions les contenant ainsi que les utilisations de tels dérivés. Les composés décrits dans cette invention se fixent à la transcriptase inverse, et sont des modulateurs, plus spécifiquement des inhibiteurs. Ces composés sont utilisés pour le traitement de divers troubles, y compris ceux impliquant l'inhibition de la transcriptase inverse. Entre autres troubles concernés, figurent ceux causés par le virus de l'immunodéficience humaine (VIH) et des rétrovirus génétiquement associés, tels que le syndrome d'immunodéficience acquise (SIDA).

Affiliated with

Also associated with

Rating

Pyrazole derivatives as reverse transcriptase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrazole derivatives as reverse transcriptase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazole derivatives as reverse transcriptase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1799489