Peptides presented by cells

Details Peptides presented by cells Peptides presented by cells

G - Physics

01

N

G01N 33/554 (2006.01) A61K 39/085 (2006.01) A61K 39/145 (2006.01) C07K 14/11 (2006.01) C07K 14/31 (2006.01) C07K 16/46 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2417767

The present invention relates to methods to determine peptides presented on the surface of mammalian cells following addition to the cells of a protein. The present invention also relates to diagnostic tests based on the determination of such peptides or modified molecules resulting from determination of such peptides, such as pharmaceutical entities preferably having specific biological activity and reduced or enhanced immunogenicity when compared with the corresponding non-modified molecules. The methods according to this invention are preferably established with tools using mass spectroscopy (MS).

L'invention concerne des procédés de détermination de la présence de peptides à la surface de cellules de mammifères suite à l'adjonction d'une protéine aux cellules. La présente invention concerne également des tests de diagnostic basés sur la détermination de ces peptides ou molécules modifiés résultant de la détermination de ces peptides, ces entités pharmaceutiques possèdent de préférence une activité biologique spécifique et une immunogénécité réduite ou renforcée, lorsque l'on compare celle-ci aux molécules non-modifiées correspondantes. Les procédés décrits dans la présente invention seront établis de préférence avec des outils utilisant la spectroscopie de masse (MS).

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