Substituted (quinolin-2-yl-methoxy)phenylthioureas

Details Substituted (quinolin-2-yl-methoxy)phenylthioureas Substituted (quinolin-2-yl-methoxy)phenylthioureas

C - Chemistry, Metallurgy

07

D

167/226, 260/287

C07D 215/12 (2006.01) A61K 31/47 (2006.01) C07D 215/14 (2006.01) C07D 215/16 (2006.01)

Patent

CA 2028042

ABSTRACT OF THE DISCLOSURE Substituted (quinolin-2-ylmethoxy)phenyl-thio- ureas of the formula Image (I) in which A, B, D, E, G, K and M - represent hydrogen, hydroxyl, halogen, carboxyl, nitro, trifluoromethyl or trifluoromethoxy, or - represent alkyl, alkoxy or alkoxycarbonyl, or - represent aryl, which is optionally substituted by halogen, hydroxyl, nitro or cyano, R1 - represents hydrogen or alkyl, which is optionally substituted by aryl or cycloalkyl, or - represents cycloalkyl, R2 _ represents alkyl, which is optionally substituted by halogen or hydroxy, or - represents cycloalkyl, which is optionally substituted by halogen or cyano, or - represents aryl which is optionally substituted by halogen, nitro, cyano, alkyl, or by -SO2-R3, in which R3 - denotes alkyl or -NR4R5, in which R4 and R5 denote hydrogen, alkyl or phenyl, or R2 - represents -CO-R6, in which R6 - denotes alkyl or aryl which is optionally substituted by halogen, nitro or cyano, Le A 27 261 and their salts, are useful for the inhibition of enzymatic reactions in the context of arachidonic acid metabolism. Le A 27 261

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