Outer membrane vesicle (omv) vaccine comprising n....

Details Outer membrane vesicle (omv) vaccine comprising n.... Outer membrane vesicle (omv) vaccine comprising n....

A - Human Necessities

61

K

A61K 39/095 (2006.01) A61K 39/116 (2006.01) A61K 39/295 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2397508

A composition comprising (a) Neisseria meningitidis serogroup B outer membrane vesicles (OMVs), and (b) an immunogenic component selected from other Neisseria proteins, or immunogenic fragments thereof. Component (b) preferably includes a protein from a different NmB strain from that from which the OMV of component (a) is derived. The OMVs are preferably obtained by deoxycholate extraction. Optionally, the composition may also comprise a protective antigen against other pathogens.

La présente invention concerne une composition comprenant (a) des vésicules de membrane externe (OMV) du sérogroupe B de (Neisseria meningitidis, et (b) un composant immunogène sélectionné parmi d'autres protéines de Neisseriaou des fragments immunogènes de celui-ci. Ce composant (b) comprend, de préférence, une protéine issue d'une souche NmB différente de celle dont est issue la vésicule de membrane externe (OVM) du composant (a). Ces OMV sont obtenues de préférence par extraction de désoxycholate. Cette composition peut aussi éventuellement comprendre un antigène de protection contre d'autres agents pathogènes.

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