Novel targeted delivery system for bioactive agents

Details Novel targeted delivery system for bioactive agents Novel targeted delivery system for bioactive agents

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 9/51 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2493596

Novel targeted delivery systems for bioactive agents. In preferred form, the delivery systems comprise, in combination with an effective amount of a bioactive agent, a targeted matrix comprising a polymer and a targeting ligand. Preferably, the targeting ligand is covalently associated with the polymer and the bioactive agent is associated non-covalently with the polymer. Also in preferred embodiments, the bioactive agent is substantially homogeneously dispersed throughout the matrix. The compositions are particularly suitable as delivery vehicles with bioactive agents that have limited water solubility .

Cette invention porte sur de nouveaux systèmes d'administration ciblée pour des agents bioactifs. Selon une variante préférée, ces systèmes d'administration comprennent, en combinaison avec une quantité efficace d'un agent bioactif, une matrice ciblée renfermant un polymère et un ligand de ciblage. Ce ligand de ciblage est de préférence associé de façon covalente au polymère alors que l'agent bioactif est associé de façon non covalente au polymère. En outre, dans des modes de réalisations préférés de cette invention, l'agent bioactif est réparti de manière sensiblement homogène dans la matrice. Les compositions sont particulièrement bien adaptées pour servir de vecteurs d'administration pour des agents bioactifs qui présentent une solubilité dans l'eau limitée.

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