Small interfering rna molecules against ribonucleotide...

Details Small interfering rna molecules against ribonucleotide... Small interfering rna molecules against ribonucleotide...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7105 (2006.01) A61K 48/00 (2006.01) A61P 35/04 (2006.01) C07H 21/02 (2006.01)

Patent

CA 2577036

Small interfering RNA (siRNA) molecules that target a mammalian ribonucleotide reductase gene, and which are capable of inhibiting the expression of their target gene are provided. The siRNA molecules of the invention are capable of attenuating neoplastic cell growth and/or proliferation in vitro and in vivo and, therefore, can be used to attenuate the growth and/or metastasis of various types of mammalian cancers.

L'invention concerne des molécules de petit ARN interférant qui ciblent un gène de la ribonucléotide réductase et qui sont capables d'inhiber l'expression de leur gène cible. Ces molécules de petit ARN interférant peuvent atténuer la croissance et/ou la prolifération de cellules néoplasiques in vitro et in vivo et, peuvent être ainsi utilisées pour atténuer la croissance et/ou la métastase de divers types de cancers de mammifères.

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