Treatment of neurological deficits in the striatum or...

Details Treatment of neurological deficits in the striatum or... Treatment of neurological deficits in the striatum or...

A - Human Necessities

61

K

A61K 38/18 (2006.01)

Patent

CA 2582226

The present invention is directed to methods of treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human by administering human recombinant GDF5 to the striatum or substanta nigra pars compacta of a human in amounts effective to induce cell populations having the capacity to differentiate towards a dopaminergic phenotype to in fact differentiate towards a dopaminergic phenotype, and to neurotrophic compositions and matrices suitable for use in such treatments.

L'invention porte sur des procédés de traitement chez l'humain de déficits neurologiques du striatum ou de la substanta nigra pars compacta résultant de lésions ou de maladies les affectant, en administrant au striatum ou à la substantia nigra pars compacta des GDF5 humaines de recombinaison en quantités suffisantes pour induire des populations de cellules présentant la capacité de se différencier en phénotypes dopaminergiques. L'invention porte également sur des compositions et matrices utilisables dans de tels traitements.

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