Methods for treatment of insulin-like growth factor-1...

Details Methods for treatment of insulin-like growth factor-1... Methods for treatment of insulin-like growth factor-1...

A - Human Necessities

61

K

A61K 38/30 (2006.01)

Patent

CA 2538342

The present invention provides methods and compositions for increasing the growth rates, alleviating the symptoms, or improving the metabolism of human patients having insulin-like growth factor-1 deficiency (IGFD). The invention relates to methods comprising administering insulin-like growth factor-I to a patient having a height which, at the time of treatment or prior to initial treatment with IGF-1, is at least about 2 standard deviations below normal for a subject of the same age and gender, a blood level of insulin-like growth factor-I that, and at the time of treatment or prior to initial treatment with IGF-1, is below normal mean levels, usually at least about 1 standard deviations below normal mean levels, for age and gender.

L'invention concerne des méthodes et des compositions permettant d'accroître les vitesses de croissance, de soulager les symptômes ou d'améliorer le métabolisme de patients humains souffrant d'une déficience du facteur de croissance de type insuline 1 (IGFD). L'invention concerne également des méthodes consistant à administrer un facteur de croissance de type insuline I à un patient dont la grandeur, au moment du traitement ou avant un traitement initial au moyen de IGF-1, est d'au moins environ 2 écarts-types au-dessous de la norme pour un sujet du même âge et du même sexe et dont le niveau sanguin du facteur de croissance de type insuline I, au moment du traitement ou avant le traitement initial au moyen IGF-1, est inférieur à des niveaux moyens normaux, généralement au moins environ 1 écart-type au-dessous des niveaux moyens normaux, pour l'âge et le sexe.

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