Process for the preparation of losartan potassium

Details Process for the preparation of losartan potassium Process for the preparation of losartan potassium

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/4178 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2608245

The invention relates to the preparation of losartan and losartan potassium. More particularly, the invention relates to the preparation of losartan and losartan potassium in a simplified process that provides higher purity losartan potassium and losartan potassium having larger crystal sizes. The invention further includes formulating into readily usable dosage units for the therapeutic treatment (including prophylactic treatment) of mammals, including humans.

L'invention concerne la préparation de losartan et de ses sels (tels que le losartan potassique). L'invention concerne plus particulièrement la préparation de losartan et de ses sels (tels que le losartan potassique) par un processus simplifié permettant d'obtenir un losartan potassique présentant une pureté accrue et de plus grandes tailles de cristaux. L'invention concerne en outre la préparation de losartan, de ses sels (tels que le losartan potassique) et/ou de promédicaments de ceux-ci clivables in vivo (regroupés sous la désignation de "composés selon l'invention") sous forme d'unités de dosage faciles à utiliser pour le traitement thérapeutique (notamment le traitement prophylactique) des mammifères, y compris de l'homme.

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