A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/381 (2006.01) C07D 327/04 (2006.01)
Patent
CA 2528587
The invention provides novel non-.beta.-lactam inhibitors of .beta.- lactamases. In particular, the invention provides boronic acid-based compounds set forth in the specification. These compounds may be used with .beta.-lactam antibiotics to bacterial infection, particularly .beta.-lactam-antibiotic- resistant bacterial infections. These compounds are also antibacterial agents by themselves. The invention further provides methods of using such compounds. Finally, the invention provides a pharmaceutical composition comprising these compounds.
L'invention concerne de nouveaux inhibiteurs de .szlig.-lactamases non .szlig.-lactamines. L'invention concerne en particulier des composés à base d'acide boronique tels que définis dans la description. Ces composés peuvent être utilisés avec des antibiotiques .szlig.-lactamines destinés à lutter contre une infection bactérienne, en particulier contre des infections bactériennes résistant aux antibiotiques .szlig.-lactamines. Ces composés constituent eux-mêmes des agents antibactériens. L'invention concerne en outre des méthodes d'utilisation desdits composés, ainsi qu'une composition pharmaceutique comprenant lesdits composés.
Freire Ernesto
Luque Irene
Ottenbrite Raphael
Ross Patrick
Xiao Yingxin
Fulcrum Pharmaceuticals Inc.
Robic
The Johns Hopkins University
LandOfFree
.beta.-lactamase inhibitors and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with .beta.-lactamase inhibitors and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .beta.-lactamase inhibitors and methods of use thereof will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1801316