Spectroscopic method and apparatus for analyte measurement

Details Spectroscopic method and apparatus for analyte measurement Spectroscopic method and apparatus for analyte measurement

G - Physics

01

N

G01N 21/27 (2006.01) B01L 3/00 (2006.01) G01N 21/01 (2006.01) G01N 21/31 (2006.01) G01N 33/48 (2006.01) G01N 33/49 (2006.01)

Patent

CA 2503849

An apparatus and method for spectroscopic measurement of an analyte in a sample is provided. The apparatus comprises a source of electromagnetic radiation (EMR) producing a light path, an aperture located within the light path and between the EMR source and a sample slot, and a photodector. The apparatus also has a primary calibration algorithm that is in operative association with the spectroscopic apparatus. Examples of analytes that may be measured using this apparatus include, but are not limited to Total-Hemoglobin, Met-Hemoglobin, Hemoglobin-based blood substitutes and any Met-Hemoglobin equivalent. The measurement of Met- Hemoglobin may be used to provide an accurate measurement of Total-Hemoglobin in whole blood, or Hemoglobin when used as an indicator of hemolysis. The measurement of Met-Hemoglobin may also be also used as a means of monitoring the degradation or reversal of degradation of Hemoglobin-based blood substitutes, or as a means of monitoring the oxidation or reversal of oxidation of Hemoglobin to Met- Hemoglobin.

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