Potent and selective mediators of cholesterol efflux

Details Potent and selective mediators of cholesterol efflux Potent and selective mediators of cholesterol efflux

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01)

Patent

CA 2672131

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

L'invention concerne une famille de polypeptides ne survenant pas de manière naturelle et munis d'une activité d'efflux de cholestérol parallèle à celle d'apolipoprotéines de pleine longueur (par exemple Apo AI, et Apo E) ainsi que d'une sélectivité élevée pour ABAC1 qui est parallèle à celle d'apolipoprotéines de pleine longueur. L'invention fournit également des compositions comprenant de tels polypeptides, des procédés d'identification, de criblage et de synthèse de tels polypeptides ainsi que des procédés de traitement, de prévention ou de diagnostic de maladies et de troubles associés à la dyslipidémie, l'hypercholestérolémie, et une inflammation.

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