Use of nitrogen oxide species and adducts to inhibit...

Details Use of nitrogen oxide species and adducts to inhibit... Use of nitrogen oxide species and adducts to inhibit...

A - Human Necessities

61

K

A61K 31/13 (2006.01) A61K 31/095 (2006.01) A61K 31/185 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 31/22 (2006.01) A61K 31/28 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/403 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/54 (2006.01) A61K 31/5415 (2006.01) A61K 31/549 (2006.01) A61K 31/675 (2006.01) A61K 33/00 (2006.01) A61K 38/05 (2

Patent

CA 2194991

A method for inhibiting or relaxing skeletal muscle contractions which comprises contacting said skeletal muscle with a skeletal muscle relaxing amount, and a method for the treatment of disease states resulting from or exacerbated by undesirable contractions of skeletal muscle, which comprises administering a skeletal muscle relaxing amount to an individual in need thereof of a compound selected from the group consisting of nitroxyl ion (NO- ), nitrosonium ion (NO+), nitric oxide and nitric oxide adducts or providers. This invention also is directed to stimulating the contraction of muscles in a mammal by administering an effective amount of a nitric oxyde synthase inhibitor.

L'invention se rapporte à un procédé d'inhibition ou de décontraction des muscles squelettiques qui consiste à mettre en contact le muscle squelettique avec une dose décontractant les muscles, et à un procédé de traitement d'états pathologiques induits ou exacerbés par des contractions indésirables du muscle squelettique, qui consiste à administrer une dose décontractant les muscles à un patient en ayant besoin, d'un composé sélectionné dans le groupe constitué par un ion nitroxyle (NO?-¿), un ion nitrosonium (NO?+¿), l'oxyde nitrique et des adjuvants ou promoteurs d'oxyde nitrique. Cette invention se rapporte également à un procédé de stimulation de la contraction musculaire chez un mammifère, consistant à administrer une dose efficace d'un inhibiteur de la synthase de l'oxyde nitrique.

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