Novel adenoviral vectors for gene therapy

Details Novel adenoviral vectors for gene therapy Novel adenoviral vectors for gene therapy

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A61K 38/22 (2006.01) A61K 48/00 (2006.01) C07K 14/575 (2006.01) C12N 5/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2329947

Helper dependent adenoviral vectors are suitable for use in gene therapy, as they are stable, contain only a very small amount less than about 0.5 % of helper virus contamination, and are less immunogenic than previous adenoviral vectors. The only viral DNA in the vectors are ITRs and packaging signals, and overall size is about 26-38 kb.

L'invention porte sur des vecteurs adénoviraux dépendant des cellules auxiliaires et pouvant d'utiliser en thérapie génique du fait de leur stabilité, de leur très faible contenu (moins de 0,5%) de virus auxiliaires contaminants, et de leur caractère moins immunogène que les vecteurs adénoviraux antérieurs. Les seuls ADN viraux des vecteurs sont des signaux ITR et d'emballage et leur longueur totale est comprise entre environ 26 et 38 kb.

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