Ret ligand (retl) for stimulating neural and renal growth

Details Ret ligand (retl) for stimulating neural and renal growth Ret ligand (retl) for stimulating neural and renal growth

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2496906

The invention relates to nucleotide sequences which encode a Ret ligant (RetL), as well as to methods of stimulting neural and renal growth by treating cells and mammalian subjects with Retl DNA or protein. The invention provides a purified and isolated DNA molecule coding for a Retl, having the nucleotide sequence of any Retl, but specifically including rat retl 1 cDNA (SEQ ID NO.1), partial human Retl 1 cDNA (SEQ ID NO:8), full length human retl 1 cDNA (SEQ ID NO:10), human retl2 cDNA (SEQ ID NO:12), murine retl3 cDNA (SEQ ID NO:16), partial human retl3 cDNA (SEQ ID NO:18) or human retl3 cDNA (SEQ ID NO:20). The invention further provides a Retl protein, with an amino acid sequence comprising that or rat Retl 1 (SEQ ID NO:2), partial human Retl 1(SEQ ID NO:9), full length human Retl (SEQ ID NO:11), human Retl2 (SEQ ID NO:13), murine Retl3 (SEQ ID NO:17), partial human Retl3 (SEQ ID NO:19) or human Retl3 (SEQ ID NO:21).

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