Humanized cdr-grafted anti-icam-1 antibodies, methods of...

Details Humanized cdr-grafted anti-icam-1 antibodies, methods of... Humanized cdr-grafted anti-icam-1 antibodies, methods of...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) G01N 33/564 (2006.01) G01N 33/567 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2081478

2081478 9116927 PCTABS00008 The present invention discloses humanized CDR-grafted antibodies which are capable of binding to the intercellular adhesion molecule ICAM-1. These antibodies are useful in treating specific and non-specific inflammation, rhinoviral infection, HIV infection, the dissemination of HIV infected cells, and asthma. In addition, the humanized antibodies disclosed can be useful in methods of diagnosing and localizing sites of inflammation and infection and tumors expressing ICAM-1.

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