Nebulizer for aerosol drug delivery

Details Nebulizer for aerosol drug delivery Nebulizer for aerosol drug delivery

A - Human Necessities

61

M

A61M 16/00 (2006.01)

Patent

CA 2531251

A method for the capture, return, and reaerosolization of undelivered aerosol with a neonatal jet nebulizer is described. The method involves the placement of an entraining jet and an impaction surface into the expiratory line of a neonatal ventilator- nebulizer setup, where the jet entrains unused medical aerosol and deposits it onto an impaction surface. The deposited solution is then returned to the nebulizer reservoir in a feedback tube. As a result, more of the initial dosage is delivered to the patient. The fraction of the dosage delivered to a filter connected to a passive neonatal test lung was compared between the situations with and without feedback. A statistically significant improvement was observed for the situation with feedback, with up to 60% more aerosol delivered for a ventilator setting of 7.5 cm H 2 0 [0.74 kPa] (.apprxeq. 6 mL tidal volume) and 40 breaths per minute (inspiratory-to-expiratory ratio of 3:7). Further device improvements may enhance the clinical efficacy of jet nebulizers in ventilated newborns. Key Words: neonatal, respiratory drug delivery, inhaled pharmaceutical aerosol, intubated, pediatric intensive care

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