A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/444 (2006.01) A61K 31/496 (2006.01) A61K 31/4985 (2006.01) A61K 31/5513 (2006.01)
Patent
CA 2629199
The present invention is based, in part, on our discovery that certain types of therapeutic agents can be used in combination to treat a variety of neuropsychiatric and related disorders, including addiction (e.g., to a substance or to an activity) as well as to alleviate some of the symptoms experienced during menopause or associated with the menstrual cycle. Regardless of the precise formulation, the compositions of the invention can include at least one active ingredient that targets the hypothalamo- pituitary- adrenal (HPA) axis and at least one active ingredient that targets the prefrontal cortex. Either or both of these types of agents can be combined with an agent that inhibits activity in the sympathetic nervous system. Thus, the compositions or combination pharmacotherapies can also include an agent that inhibits a beta-adrenergic receptor or that otherwise acts as an anti- hypertensive or anxiolytic agent.
La présente invention est basée d'une part sur la découverte que certains types d'agents thérapeutiques peuvent être utilisés en combinaison pour traiter différents troubles neuropsychiatriques et troubles associés, notamment l'addiction (par exemple à une substance ou à une activité) ainsi que pour soulager certains des symptômes subis lors de la ménopause ou associés au cycle menstruel. Quelle que soit leur formulation précise, les compositions selon l'invention peuvent contenir au moins un ingrédient actif qui cible l'axe hypothalamo-pituitaire-adrénalien (HPA) et au moins un ingrédient actif qui cible le cortex préfrontal. L'un de ces types d'agents ou les deux peuvent être combinés avec un agent qui inhibe l'activité du système nerveux sympathique. Ainsi, les compositions ou les pharmacothérapies combinées peuvent également comprendre un agent qui inhibe un récepteur béta-adrénergique ou qui agit d'une autre manière comme agent anti-hypertensif ou agent anxiolytique.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Supervisors Of Louisiana State University & Agricultura
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