Novel amidine derivatives, preparation and use thereof as...

Details Novel amidine derivatives, preparation and use thereof as... Novel amidine derivatives, preparation and use thereof as...

C - Chemistry, Metallurgy

07

D

C07D 333/38 (2006.01) A61K 31/381 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2391598

The invention concerns novel amidine derivatives, their preparation and their use as medicines. It concerns in particular the use of said derivatives for preparing a medicine designed to inhibit NO synthases and/or monoamine oxydases. More particularly, it concerns the following compounds: -N'-(4-{[methyl-(2-propynyl)amino]methyl}phenyl)-2-thiophenecarboximidamide; N'-(4-{[methyl(cyanomethyl)amino]methyl}phenyl)-2-thiophenecarboximidamide; N'-(4-{[methyl(propyl)amino]methyl}phenyl)-2-thiophenecarboximidamide; N'-(4-{[methyl(3-cyanoethyl)amino]methyl}phenyl)-2-thiophenecarboximidamide; N'-(4-{[methyl(4-pentynyl)amino]methyl}phenyl)-2-thiophenecarboximidamide; or their salts.

La présente invention concerne de nouveaux dérivés d'amidines, leur préparation et leur application à titre de médicaments. Elle concerne en particulier l'utilisation desdits dérivés pour préparer un medicament destiné à inhiber les NO synthases et/ou les monoamine oxydases. Elle a en particulier pour objet les composés suivants: N'-(4-{[méthyl-(2- propynyl)amino]méthyl}phényl)-2-thiophènecarboximidamide; N'-(4- {[méthyl(cyanométhyl)amino]méthyl}phényl)-2-thiophènecarboximidamide; N'-(4- {[méthyl(propyl)amino]méthyl}phényl)-2-thiophènecarboximidamide; N'-(4- {[méthyl(3-cyanoéthyl)amino]méthyl}phényl)-2-thiophènecarboximidamide; N'-(4- {[méthyl(4-pentynyl)amino]méthyl}phényl)-2-thiophènecarboximidamide; ou leurs sels.

Affiliated with

Also associated with

Rating

Novel amidine derivatives, preparation and use thereof as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel amidine derivatives, preparation and use thereof as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel amidine derivatives, preparation and use thereof as... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1803151