Gel-stabilized nanoparticulate active agent compositions

Details Gel-stabilized nanoparticulate active agent compositions Gel-stabilized nanoparticulate active agent compositions

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 31/192 (2006.01)

Patent

CA 2498207

Disclosed is a solid or semi-solid gelatin nanoparticulate active agent dosage form comprising at least one nanoparticulate active agent and at least one glel forming substance which exhibits gelation sufficient to retain excess water in the solid or semi-solid gelatin form. The active agent particles have an effective average diameter prior to inclusion in the dosage form of less than about 2000 mn. The dosage form of the invention has the advantages of easy administration combined with rapid dissolution of the active agent following administration.

L'invention concerne une forme dosifiée d'agent actif nanoparticulaire de gélatine solide ou semi-solide contenant au moins un agent actif nanoparticulaire et au moins une substance de formation de gel présentant une gélification suffisante pour retenir un excès d'eau sous la forme de gélatine solide ou semi-solide. Les particules de l'agent actif ont un diamètre moyen efficace avant leur inclusion dans la forme dosifiée qui est inférieur à environ 2000 mn. La forme dosifiée de cette invention possède les avantages d'une administration facile combinée à une dissolution rapide de l'agent actif, suite à une administration.

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