Use of histamine as a drug delivery enhancing compound for...

A - Human Necessities – 61 – K

Patent

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A61K 47/22 (2006.01)

Patent

CA 2393452

A transmucosally administrable composition with enhanced penetration comprising: about 0.001 % to about 25 % of a permeation enhancing agent selected from the group consisting of histamine, histamine dihydrochloride, histamine phosphate, a pharmaceutically acceptable salt thereof, other histamine agonists, about 0.2 % to about 90 % of a pharmaceutically active medicament, about 0 % to about 99.8 % of solvent, and about 0 % to about 50 % of a gelling agent.

La présente invention concerne une composition à administration transmuqueuse à pénétration améliorée comprenant: entre environ 0,001 % et environ 25 % d'un agent améliorant la perméation choisi dans le groupe composé de l'histamine, du dichlorhydrate d'histamine, du phosphate d'histamine, d'un sel pharmaceutiquement acceptable de ces derniers, d'autres agonistes de l'histamine; entre environ 0,2 % et environ 90 % d'un médicament pharmaceutiquement actif; entre environ 0 % et environ 99,8 % d'un solvant; et entre environ 0 % et environ 50 % d'un agent gélifiant.

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