Manufacture process of n-substituted salicylamides

C - Chemistry – Metallurgy – 07 – C

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C07C 235/60 (2006.01) A61K 47/18 (2006.01) C07C 231/08 (2006.01) C07C 233/24 (2006.01) C07C 235/58 (2006.01) C07D 265/26 (2006.01)

Patent

CA 2587213

The present invention relates to a method of preparing N-substituted salicylamides or derivatives thereof, and their salts, hydrates and solvates. In particular, the present invention relates to a method of preparing N-(5- chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC) and its corresponding disodium monohydrate.

La présente invention a pour objet une méthode de synthèse de salicylamides N-substitués ou de dérivés desdits salicylamides, ainsi que de leurs sels, hydrates, et solvates. La présente invention a plus particulièrement pour objet une méthode de préparation de l'acide N-(5-chlorosalicyloyl)-8-aminocaprylique (5-CNAC) ainsi que du monohydrate disodique correspondant.

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