Pyrimidines derivatives and their use as kinase inhibitors

Details Pyrimidines derivatives and their use as kinase inhibitors Pyrimidines derivatives and their use as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2661938

At least one chemical entity chosen from compounds of Formula 1 and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof, is described herein. Pharmaceutical compositions comprising at least one chemical entity of Formula 1, together with at least one pharmaceutically acceptable vehicle chosen from carriers adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/ or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.

L'invention concerne au moins une entité chimique choisie à partir de composés de formule 1, ainsi que des sels, des solvates, des chélates, des complexes non covalents et des promédicaments pharmaceutiquement acceptables, ainsi que des mélanges de ceux-ci. L'invention concerne également des compositions pharmaceutiques contenant au moins une entité chimique de formule 1, au moins un excipient pharmaceutiquement acceptable choisi parmi des vecteurs adjuvants, et des excipients. L'invention concerne encore des méthodes de traitement de patients atteints de certaines maladies répondant à l'inhibition de l'activité Btk et/ou de l'activité des lymphocytes B. L'invention concerne enfin des méthodes permettant de détecter la présence de Btk dans un échantillon.

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