C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/10 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61K 31/675 (2006.01) A61P 31/04 (2006.01) C07D 263/20 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2529292
This invention relates to new oxazolidin,41-es having a C" cl ropyl moiety, which are effective against aerobic and anerobic pathogen I esistant staphylococci, streptococci and enterococci, Bacteroides s Cl' idia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosis and other mycobacterial species. 10 The compounds are represented by structural formula (I): A a Rx (R4a)s Rx x 1 0 Ri Ar or HAr N 0 A \_R3 15 its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof.
La présente invention concerne de nouvelles oxazolidinones représentées par la formule structurelle (I), ses énantiomères, diastéréomères, ou certains de leurs sels ou esters pharmaceutiquement admis. Ces nouvelles oxazolidinones, qui portent un groupe fonctionnel cyclopropyle, sont efficaces contre des gènes pathogènes aérobies et anaérobies tels que les staphylocoques, streptocoques et entérocoques multirésistants, les bactéroïdes, Clostridium, ainsi que les organismes résistant aux acides tels que Mycobacterium tuberculosis et autres mycobactéries.
Fukuda Yasumichi
Hammond Milton L.
Kyorin Pharmaceutical Co. Ltd.
Merck & Co. Inc.
Robic
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