Pharmaceutical formulations for protecting pharmaceutical...

A - Human Necessities – 61 – K

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A61K 31/4439 (2006.01) A01N 33/02 (2006.01) A61K 31/13 (2006.01) A61K 33/00 (2006.01) A61K 33/08 (2006.01) A61K 33/10 (2006.01) A61K 45/00 (2006.01) A61K 45/08 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01) A61P 1/04 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2460987

Methods and pharmaceutical compositions for protecting pharmaceutical compounds (or drugs) in acidic environments are provided. Methods of treatment using formulations capable of protecting pharmaceutical compounds in acidic environments are also provided. Formulations provided generally comprise a therapeutically effective amount of at least one pharmaceutical compound, and a pharmaceutically acceptable protectant. The pharmaceutically acceptable protectant of the invention generally comprises a water-soluble acid neutralizer, and a water-insoluble acid neutralizer.

L'invention concerne des procédés et des compositions pharmaceutiques pour la protection de composés pharmaceutiques (ou de médicaments) contre des milieux acides. L'invention concerne également des procédés de traitement reposant sur l'utilisation de formulations capables de protéger des composés pharmaceutiques contre des milieux acides. Par ailleurs, l'invention concerne en règle générale des formulations qui renferment une quantité d'au moins un composé pharmaceutique, efficace du point de vue thérapeutique, et un agent de protection pharmaceutiquement acceptable. Cet agent renferme en règle générale un agent de neutralisation d'acide hydrosoluble, et un agent de neutralisation d'acide insoluble dans l'eau.

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