A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01)
Patent
CA 2538999
The methods and compositions of the present invention find use in altering expression of PKC.alpha. in transgenic animals. The compositions of the invention include isolated transgenic animal cells, transgenic tissue, transgenic animals, and transgenic mice. The transgenic animals of the invention exhibit altered PKC.alpha. activity. The methods allow generation of transgenic animals with altered expression of PKC.alpha.. The invention allows modulation of cardiac contractility. In particular, the invention provides a method for altering the susceptibility of a transgenic animal to cardiomyopathy. A transgenic animal of the invention finds use in identifying anti-cardiomyopathic compounds.
La présente invention a trait à des procédés et des compositions utiles dans la modification de l'expression de la protéine kinase C-alpha (PKC.alpha.) chez des animaux transgéniques. Les compositions de l'invention comprennent des cellules animales transgéniques isolées, du tissu transgénique, des animaux transgéniques, et des souris transgénique. Les animaux transgéniques de l'invention présentent une activité de PKC.alpha. modifiée. Les procédés permettent la génération d'animaux transgéniques à expression modifiée de PKC.alpha.. L'invention permet la modulation de la contractilité cardiaque. En particulier, l'invention fournit un procédé pour la modification de la susceptibilité d'un animal transgénique à la cardiomyopathie. Un animal transgénique de l'invention trouve une application dans l'identification de composés contre la cardiomyopathie.
Kranias Evangelia Galani
Molkentin Jeffery Daniel
Children's Hospital & Medical Center
Torys Llp
University Of Cincinnati
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