C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/12 (2006.01) A61K 39/40 (2006.01) C07K 14/20 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2076855
2076855 9113096 PCTABS00007 The invention relates to novel antigens associated with Borrelia burgdorferi which are exported (or shed) in vivo and whose detection is a means of diagnosing Lyme disease. The antigens are extracellular membrane vesicles and other bioproducts including the major extracellular protein. The invention is further directed to antibodies, monoclonal and/or polyclonal, labeled and/or unlabeled, that react with the antigens and to a method of diagnosing Lyme disease by detecting the antigens in a biological sample taken from a host using the antibodies in conventional immunoassay formats. The invention further relates to kits, for the diagnosis of Lyme disease, comprising the antibodies and ancillary reagents. The advantage of the antibodies used in the invention is that they react with the antigens from geographically diverse strains of Borrelia burgdorferi, but do not react with antigens from related Borrelia spirochetes.
Dorward David W.
Garon Claude F.
Schwan Tom G.
Gowling Lafleur Henderson Llp
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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