C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/58 (2006.01) A61K 31/35 (2006.01)
Patent
CA 2105158
2105158 9217426 PCTABS00016 Retinoid like activity is exhibited by compounds of formula (I), wherein the R1-R6 groups are independently H or straight chain or branched chain lower alkyl or cycloalkyl of 1 to 6 carbons; X symbolizes an ester or thioester linkage, Y is lower branched chain alkyl having 2 to 6 carbons, cycloalkyl having 3 to 6 carbons or is (CH2)n where n is an integer between 0 to 6 or is an alkenyl group of 2 to 6 carbons, and having 1 or 2 double bonds, or an alkynyl group of 2 to 6 carbons; and Z is H, OH, OR', OCOR', -COOH or a pharmaceutically acceptable salt, COOR8, COONR9R10, -CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12), CHOR13O, -COR', CR'(OR12)2, or CR'OR13O; where R' is an alkyl, cycloalkyl or alkenyl group containing 1-5 carbons, R8 is an alkyl group of 1-10 carbons, or a cycloalkyl group of 5-10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently are hydrogen, an alkyl group of 1-10 carbons, or a cycloalkyl group of 5-10 carbons or phenyl or lower alkyl phenyl, R11 is lower alkyl, and R13 is a divalent alkyl radical of 2-5 carbons.
Allergan Inc.
Gowling Lafleur Henderson Llp
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